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Home - Products - GPCR/G Protein - Neurotensin Receptor - SR 48692

SR 48692

CAS No. 146362-70-1

SR 48692( Meclinertant | SR48692 | SR-48692 )

Catalog No. M11989 CAS No. 146362-70-1

A potent, selective and orally active nonpeptide antagonist of the neurotensin receptor with IC50 of 0.99 nM.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    SR 48692
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective and orally active nonpeptide antagonist of the neurotensin receptor with IC50 of 0.99 nM.
  • Description
    A potent, selective and orally active nonpeptide antagonist of the neurotensin receptor with IC50 of 0.99 nM (guinea pig), without any intrinsic agonist activity; blocks K(+)-evoked release of [3H]dopamine stimulated by neurotensin in guinea pig striatal slices with IC50 of 0.46 nM, competitively antagonizes neurotensin-induced intracellular Ca2+ mobilization with pA2 of 8.13 in H29 cells; reverses the turning behavior induced by intrastriatal injection of neurotensin in mice.Lung Cancer Phase 2 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Meclinertant | SR48692 | SR-48692
  • Pathway
    GPCR/G Protein
  • Target
    Neurotensin Receptor
  • Recptor
    Neurotensin Receptor
  • Research Area
    Cancer
  • Indication
    Lung Cancer

Chemical Information

  • CAS Number
    146362-70-1
  • Formula Weight
    587.073
  • Molecular Formula
    C32H31ClN4O5
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(NC1(C(O)=O)[C@H]2C[C@@H]3C[C@@H](C[C@H]1C3)C2)C4=NN(C5=CC=NC6=CC(Cl)=CC=C56)C(C7=C(OC)C=CC=C7OC)=C4
  • Chemical Name
    (1r,3r,5r,7r)-2-(1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazole-3-carboxamido)adamantane-2-carboxylic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Dubuc I, et al. Br J Pharmacol. 1994 Jun;112(2):352-4. 2. Steinberg R, et al. Neuroscience. 1994 Apr;59(4):921-9. 3. Brouard A, et al. Eur J Pharmacol. 1994 Mar 3;253(3):289-91. 4. Gully D, et al. Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):65-9.
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